At this point, a … Genetic Marker Test for Pug Dog Encephalitis Introduction. Pug Dog Genetic Tests Susceptibility to Pug Dog Encephalitis (PDE) Pyruvate Kinase Deficiency (PKDef) Pug Dog Encephalitis. That last test looks for signs of NME (Necrotizing Meningoenchephalitis), an inflammatory disease of the central nervous system that, while it only affects a small percentage of pugs, is progressive and fatal. Encephalitis literally means inflammation of the brain. NME is an inflammatory disease of the central nervous system that is usually progressive and fatal. Copyright © The Regents of the University of California, Davis campus. Additional $5 discount on 3 or more dogs. J Vet Intern Med 2008: 22: 961–968. This necrotizing and inflammatory disorder of the central nervous system causes seizures, abnormal gait, and depression. Note: This is NOT a diagnostic test for NME in Pugs or for NME disease/risk in other breeds. These dogs are 12.75 times more likely to develop NME in their lifetime. div.donation-level-general-ask, div.html-caption-container { Participate in canine health research by providing samples or by enrolling in a clinical trial. One fourth of puppies will be N/N and at low risk for NME; one half will be N/S, carry the susceptibility marker, but will also be at low risk for NME;  one fourth will be S/S and will be at high risk for NME. new test: Inflammatory Pulmonary Disease ( IPD ) in Rough and Smooth Collies new test: Lafora Disease in Basset Hound, Beagle, Chihuahua, French Bulldog, Welsh Corgi and Mini Wirehaired Dachshund new Kennel Club DNA testing schemes with LABOKLIN: • Pug Dog Encephalitis (PDE) / Necrotizing Meningoencephalitis (NME) in Pug This gene defect has been associated with an increased risk for encephalitis in Pug dogs. These dogs have a low risk of developing NME. Pugs that are S/S should not be bred from. It is also known as necrotizing meningoencephalitis. These dogs have a low risk of developing NME. These dogs are 12.75 times more likely to develop NME in their lifetime. But the test can identify Pugs that are at an increased risk for developing encephalitis and could therefore be used to screen Pugs that are going to be used for breeding. referred to as Pug Dog Encephalitis (NME) and Necrotizing Encephalitis of Yorkshire Terriers NLE), respectively, these meningoencephalitides have now been reported in numerous breeds including the pug, Maltese terrier, Chihuahua, Yorkshire terrier, Pekingese, West Highland white terrier, Boston terrier, Japanese Spitz, and miniature Pinscher. Epidemiology of necrotizing meningoencephalitis in Pug dogs. Pug dog encephalitis usually becomes symptomatic in affected pugs when they are aged between two and three, although the age of onset can be highly variable, being as early as six months old in some cases and over six in others.The progression rate of the condition can be very variable as well, with some dogs going from fine to seriously ill within just a few weeks, and then dying suddenly. All puppies will have two copies of the low NME risk markers (N/N) and will have a significantly reduced risk of developing NME during their lifetime. Greer KA, AK Wong, H Liu, TR Famula, NC Pedersen, A Ruhe, M Wallace and MW Neff. Unfortunately there is no way to test for or treat the disease. Pug Dog Encephalitis is more likely to affect female fawn coloured Pugs than male non-fawn Pugs; however you should wait for any test results to come back and make a decision with your Veterinarian about the next diagnostic steps. max-width: 1000px !important; Two copies of the NME susceptibility associated markers. Female, fawn-colored Pugs younger than 7 years of age are more apt to develop NME than older, male, and non-fawn colored individuals. We are beginning to explore ways to treat it. Symptoms of NME include seizures, depression, ataxia, abnormal gait and blindness (1). Dogs that are homozygous for the NME-susceptibility haplotype, ie, those with two identical copies of the NME-associated markers (denoted S/S) have an observed risk of 12.75 for NME in their lifetime over Pugs that have only one (N/S) or no (N/N) copies of these markers (observed risk of 0-1.08). These dogs have a low risk of developing NME. Pug Dog Encephalitis (PDE), also known as Necrotizing Meningeoncephalitis (NME) This is a problem unique to Pugs which strikes terror in the hearts of those of us who know and love them. Several genetic markers are associated with risk of developing NME. Pug Dog Encephalitis (PDE) is probably a Pug owners greatest concern and worst fear. Recent research has revealed that susceptibility to NME is associated with the dog leukocyte antigen (DLA) region of dog chromosome 12. Tested pugs may be N/N (clear of PDE), N/S (carriers, at low risk of developing PDE), or S/S (susceptible to PDE). Approximately 1.2% of Pug dogs die of necrotizing meningoencephalitis (NME), also known as Pug dog encephalitis (PDE). These dogs have a low risk of developing NME. Pug dog encephalitis (PDE) is an idiopathic inflammatory disease primarily affecting the prosencephalon (forebrain and thalamus). We don’t know exactly why Pugs get it. It could cost between $1,000 and $3,000 for diagnostics (CSF tap, MRI, blood work) and medications. One pug could show a 0.001 percent chance of having PDE, and a second could show a 4 percent chance. 8051 Arco Corporate Dr. Suite 300 Raleigh, NC 27617 (888)-682-9696,